Mixing RAM modules

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I have four slots, two are filled with 8Gb DDR3 800Mhz modules, two are empty.

Can I put two 4Gb PC3-12800 in the other two slots please?

If I can is it important what slots which goes in?

I think quantity is more important than speed for my image processing.

Will I have a problem if I simply try it?

Thank you.

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